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“There is increasing excitement over the use of viral treatments like T-VEC for cancer, because they can launch a two-pronged attack on tumours – both killing cancer cells directly and marshalling the immune system against them,” said Prof Kevin Harrington, Professor of Biological Cancer Therapies at The Institute of Cancer Research.“Because viral treatment can target cancer cells specifically, it tends to have fewer side-effects than traditional chemotherapy or some of the other new immunotherapies.The results show that 163 patients with stage three and early stage four melanoma who were treated with T-VEC lived for an average of 41 months.That was compared with an average survival of 21.5 months for 66 patients who were given the current best immunotherapy drugs.It has been genetically engineered to produce a molecule called GM-CSF, which stimulates the immune system to attack and destroy the tumour.It has also been modified to remove two key genes so that it can’t replicate within healthy cells.In a worldwide study which was led by the Institute of Cancer Research in the UK, scientists showed that the new treatment allowed some patients with skin cancer to live for more than three years – the benchmark many oncologists use to define a cure.While the breakthrough came in skin cancer patients, scientists said it raises hopes that the same process could be used for other cancers.
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